MEASUREMENT OF LUNG VOLUME BY MULTIPLE INDICATOR DILUTION

Overestimation of left ventricular volume by the indicator dilution technique.

• Since the work of Bing and co-workers and the subsequent observations of Holt, the indicator dilution technique has been used to measure ventricular volume. The validity of the technique depends upon thorough mixing of indicator with ventricular blood. However, experimental data have been presented by Irisawa et al. and subsequently by Swan and Beck suggesting that requisite mixing does not o...

Measurement of mitral regurgitation by indicator-dilution techniques.

CONSIDERABLE progress has been made in recent years in the quantitative estimation of certain cardiovalvular abnormalities by cardiac catheterization.' The quantitative determination of mitral regurgitation has not yet reached a similar status despite a substantial amount of experimental effort. This article will give theoretical bases for determination of mitral regurgitation by indicator-dilu...

Estimation of extravascular lung water by indicator-dilution techniques.

Multiple breath helium dilution measurement of lung volumes in adults.

This manuscript recommends techniques (methodology) for the measurement of total lung capacity (TLC), functional residual capacity (FRC) and residual volume (RV) in adults using the closed-circuit helium dilution method. Lung volumes were first measured using a hydrogen gas dilution technique about 200 yrs ago. Helium replaced hydrogen for safety reasons 40–50 yrs ago when clinicians started to...

Thermal dye double indicator dilution measurement of lung water in man: comparison with gravimetric measurements.

The thermal dye double indicator dilution technique for estimating lung water was compared with gravimetric analyses in nine human subjects who were organ donors. As observed in animal studies, the thermal dye measurement of extravascular thermal volume (EVTV) consistently overestimated gravimetric extravascular lung water (EVLW), the mean (SEM) difference being 3.43 (0.59) ml/kg. In eight of t...